Xenotransplantation: progress and promise

Progress towards clinical xenotransplantation.

Xenotransplantation has progressed from early heroic experiments on the path to meet the ever increasing demands of tissue and organ transplantation in patients with end-stage organ failure. The pig species is regarded as the most promising donor species. However, due to the evolutionary distance, innovative approaches are to be developed to permit life-supporting function in humans. Transplant...

Xenotransplantation-Progress and Problems: A Review

Xenotransplantation using pig cells, tissues or organs is considered to be a solution to the shortage of human allotransplants. Pigs have been selected as optimal donor for several reasons, among them physiological and economical. Before xenotransplantation will be applied broadly in the clinic three hurdles need to be overcome: (i) rejection due to immune reactions and coagulation dysfunction,...

Stroke: Challenges, Progress, and Promise

Progress in Xenotransplantation Research Employing Transgenic Pigs

Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been used for the generation of transgenic livestock. This technology works reliably, but is inefficient and results in random integration and variable expression patterns in the transgenic offspring. Nevertheless, remarkable achievements have been made with this technology with regard to xenotransplantation. ...

Melatonin in cancer management: progress and promise.

Physiologic and pharmacologic concentrations of the pineal hormone melatonin have shown chemopreventive, oncostatic, and tumor inhibitory effects in a variety of in vitro and in vivo experimental models of neoplasia. Multiple mechanisms have been suggested for the biological effects of melatonin. Not only does melatonin seem to control development alone but also has the potential to increase th...